Acute hepatitis associated with terbinafine
Vivas, S.; Rodríguez, M.; Palacio, M.A.; Cadenas, F.; Lomo, J.; Rodrigo, L.
Gastroenterologia y Hepatologia 20(9): 456-458
1997
ISSN/ISBN: 0210-5705 PMID: 9445740 Document Number: 473846
Oral terbinafine is a recently introduced antifungal drug with slight side effects that rarely includes liver involvement. A case of toxic hepatitis secondary to terbinafine administration in a patient with no previous history of liver disease and in whom other possible causes of liver damage and histologic study were performed is reported. A mixed lesion was presented with predominance of cholestasis. The initial worsening following discontinuation of the drug is of note as are the prolonged course of the enzymatic alterations which normalized at one year. The precise mechanism by which terbinafine produced liver damage is unknown and is probably due to an idiosyncratic type reaction.