Neurofibrillary tangles and neuropil threads as a cause of dementia in Parkinson's disease
Braak, H.; Braak, E.; Yilmazer, D.; de Vos, R.A.; Jansen, E.N.; Bohl, J.
Journal of Neural Transmission. Supplementum 51: 49-55
1997
ISSN/ISBN: 0303-6995 PMID: 9470128 Document Number: 473693
Alzheimer's disease (AD) and Parkinson's disease (PD) are the most common age-related degenerative disorders of the human brain. Both diseases involve multiple neuronal systems and are the consequences of cytoskeletal abnormalities. In AD susceptible neurons produce neurofibrillary changes, while in Parkinson's disease, they develop Lewy bodies. In AD six developmental stages can be distinguished on account of the predictable manner in which the neurofibrillary changes spread across the cerebral cortex. During the course of PD numerous limbic determined parts of the brain undergo specific lesions regulating endocrine and autonomic functions. In general, the extranigral destructions are in themselves not sufficient to produce overt intellectual deterioration. Fully developed Parkinson's disease with concurring incipient Alzheimer's disease is likely to cause impaired cognition.