Effectiveness of electrochemical therapy in the treatment of lung cancers of middle and late stage
Xin, Y.; Xue, F.; Zhao, F.
Chinese Medical Journal 110(5): 379-383
1997
ISSN/ISBN: 0366-6999 PMID: 9594307 Document Number: 473477
Objective: To investigate the effect of electrochemical therapy (ECT) in the treatment of middle and late-stage lung cancers. Methods: Three hundred and eighty-six cases (287 mates and 99 females aged 25 - 78, with an average age of 51 years) with middle and late-stage lung cancers were treated with ECT. Two hundred and three patients had squamous cell carcinoma, 138 adenocarcinoma and 45 undifferentiated cancer. Diameters of the cancers were respectively 4.0 - 6.0 cm in 15 3 cases, 6.1 - 8.0 cm in 82 cases, 8.1 - 10.0 cm in 102 cases and over 10.0 cm in 49 cases. In this group, none was at stage I, 103 cases were at stage I, 89 cases at II a, 122 cases at III b and 72 cases at IV. Of the 386 cases, 152 cases (39.4%) also suffered from hypertension, heart disease etc. Anode and cathode platinum electrodes were inserted accurately into the tumour mass. Distance between two electrodes was 2.0-2.5 cm. Electrodes were connected to a special ECT instrument. The current was maintained at 6 - 8 V and 80 - 100 mA. One hundred coulombs are used for treating 1 cm diameter of tumour mass. Results: Of the 386 cases, 99 cases (25.6%) achieved complete remission (CR). 179 cases (46.4%) achieved partial remission (PR), 59 cases (15. 3%) had no change (NC) and 49 cases (12.7%) had progression of disease (PD). Effective rate (CR+PR) was 72% (278 cases). One to five year survival rates were 86.3%, 76.4%, 58.8%, 39.9% and 29.5%, respectively. Conclusions: ECT is easy to use. It is effective, safe, less traumatic and makes patients recover quickly. This is a new and effective method to treat patients with turnouts who are inoperable and can not receive chemotherapy or radiotherapy.