Antimutagenicity of phenothiazine-metal co-ordination complexes in chemically induced mutagenesis
Tanaka, M.; Molnár, J.; Kidd, S.
Anticancer Research 17(1a): 381-385
1997
ISSN/ISBN: 0250-7005 PMID: 9066681 Document Number: 472981
Phenothiazines are heterocyclic organic compounds in which nitrogen and sulfur are incorporated in the tricyclic system, and are known to have antimutagenic activity by shielding DNA-base pairs. Inorganic metals have also been intensively studied for DNA-adduct formation as potential anticancer agents. Phenothiazine, promethazine, promazine and chlorpromazine were complexed either with copper, palladium or gold. The antimutagenicity of twelve phenothiazine-metal complexes, four phenothiazines and three inorganic metals was examined on Salmonella typhimurium TA98 strain treated with a strain-specific, direct-acting mutagen, 4-nitro-o-phenylene-diamine, and the ligand-DNA interaction was analyzed by ultraviolet (UV) spectrophotometry. Phenothiazine-metal co-ordination complexes generally increased their antimutagenic activity, compared to their parent compounds, and the enhanced antimutagenicity was attributed to their interaction with DNA as evidenced by the UV spectra.