RhDNase in cystic fibrosis
Conway, S.P.; Littlewood, J.M.
British Journal of Hospital Medicine 57(8): 371-372
1997
ISSN/ISBN: 0007-1064 PMID: 9274660 Document Number: 472916
Cystic fibrosis (CF) affects approximately 1 in 2500 live births in the UK Caucasian population. Morbidity and mortality closely reflect the degree of pulmonary involvement. rhDNase is a new form of therapy in CF care. Phase 1, 2 and 3 trials have shown it to be well-tolerated, with patients showing initial increases in respiratory function of around 13% from baseline. A years prescription costs $7500. This review discusses our views on how this expensive new therapy can best be used.