Evaluation of the effectiveness and safety of salmeterol in children with nocturnal dyspnea
Słomka, A.
Pneumonologia i Alergologia Polska 65(Suppl 1): 44-50
1997
ISSN/ISBN: 0867-7077 PMID: 9410301 Document Number: 472553
10 children 8-16 years old (mean = 12.9) received at least 4 inhalations of short acting beta-2-mimetics and up to 100 mcg inhaled corticosteroids or/and 5 mg oral prednisone daily. Lung function test values indicated mild/severe asthma in these patients (PEFF 50-80%, FEV1 50-80%, FEV1/VC less or equal 60%). Reversibility of obstruction was at least 15% comparing to the initial values. After two weeks of this treatment resolution of dyspnoea in the night-time and significant decrease of dyspnoea in the day-time were observed. The best bronchodilatation effect was noticed in the third and fourth week of therapy. After discontinuation of Serevent significantly milder course of dyspnoea was observed.