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Malignancy of colorectal cancer analyzed by expression of cyclin D1

Maeda, K.; Kang, S.M.; Ogawa, M.; Chung, Y.S.; Onoda, N.; Nakata, B.; Nishiguchi, Y.; Ikehara, T.; Okuno, M.; Sowa, M.

Gan to Kagaku Ryoho. Cancer and ChemoTherapy 24(Suppl 2): 259-262

1997

ISSN/ISBN: 0385-0684
PMID: 9263512
Document Number: 472075
We evaluated the clinical significance of cyclin D1 expression in colorectal adenocarcinoma. One hundred twenty-three specimens resected from patients with colorectal cancers were investigated by staining with a monoclonal antibody against cyclin D1. The possible correlations among cyclin D1 expression, clinicopathologic factors and prognosis were studied. There was no significant association between cyclin D1 expression and various clinicopathological factors. However, disease-free survival was significantly worse in the patients with cyclin D1 strongly positive tumors than in those with cyclin D1 negative tumors. Cyclin D1 overexpression may be useful as a predictor of disease recurrence in patients with colorectal adenocarcinoma.

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Zukerberg, L.R.; Yang, W.I.; Gadd, M.; Thor, A.D.; Koerner, F.C.; Schmidt, E.V.; Arnold, A. 1995: Cyclin D1 (PRAD1) protein expression in breast cancer: approximately one-third of infiltrating mammary carcinomas show overexpression of the cyclin D1 oncogene Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology Inc 8(5): 560-567
Brändstedt, J.; Wangefjord, S.; Nodin, Börn.; Eberhard, J.; Jirström, K.; Manjer, J. 2014: Associations of hormone replacement therapy and oral contraceptives with risk of colorectal cancer defined by clinicopathological factors, beta-catenin alterations, expression of cyclin D1, p53, and microsatellite-instability Bmc Cancer 14: 371
Fu, J.; Jiang, Y.-g.; Bin, X.-n.; Chen, X.-m. 2006: Study on E-cadherin, Cyclin D1 and Cyclin e expression in anti-malignant transformation by chlorophyllin Wei Sheng Yan Jiu 35(6): 678-681
Bennett, N.A.; Pattillo, R.A.; Lin, R.S.; Hsieh, C.Y.; Murphy, T.; Lyn, D. 2001: TSG101 expression in gynecological tumors: relationship to cyclin D1, cyclin E, p53 and p16 proteins Cellular and Molecular Biology 47(7): 1187-1193
Tam, S.W.; Theodoras, A.M.; Shay, J.W.; Draetta, G.F.; Pagano, M. 1994: Differential expression and regulation of Cyclin D1 protein in normal and tumor human cells: association with Cdk4 is required for Cyclin D1 function in G1 progression Oncogene 9(9): 2663-2674
Ishida, H.; Fujioka, M.; Ohsawa, T.; Takeuchi, I.; Nakada, H.; Ishizuka, N.; Yokoyama, M.; Inokuma, S.; Yamada, H.; Odaka, A.; Hoshino, T.; Murata, N.; Hashimoto, D.; Matsumoto, Y.; Miura, T. 2001: Effect of peroral doxifluridine plus hepatic arterial infusion for synchronous liver metastasis of colorectal cancer--correlation with the expression of thymidine phosphorylase and dihydropyrimidine dehydrogenase in primary colorectal cancer lesions Gan to Kagaku Ryoho. Cancer and ChemoTherapy 28(11): 1624-1627
Salh, B.; Bergman, D.; Marotta, A.; Pelech, S.L. 1999: Differential cyclin-dependent kinase expression and activation in human colon cancer Anticancer Research 19(1b): 741-748
Liang, B.; Wang, S.; Yang, X.; Ye, Y.; Yu, Y.; Cui, Z. 2003: Expressions of cyclin E, cyclin dependent kinase 2 and p57(KIP2) in human gastric cancer Chinese Medical Journal 116(1): 20-23
Joe, A.K.; Memeo, L.; Mckoy, J.; Mansukhani, M.; Liu, H.; Avila-Bront, A.; Romero, J.; Li, H.; Troxel, A.; Hibshoosh, H. 2005: Cyclin D1 overexpression is associated with estrogen receptor expression in Caucasian but not African-American breast cancer Anticancer Research 25(1a): 273-281
Ohta, T.; Okamoto, K.; Isohashi, F.; Shibata, K.; Fukuda, M.; Yamaguchi, S.; Xiong, Y. 1998: T-loop deletion of CDC2 from breast cancer tissues eliminates binding to cyclin B1 and cyclin-dependent kinase inhibitor p21 Cancer Research 58(6): 1095-1098
Brozek, W.; Kriwanek, S.; Bonner, E.; Peterlik, M.; Cross, H.S. 2009: Mutual associations between malignancy, age, gender, and subsite incidence of colorectal cancer Anticancer Research 29(9): 3721-3726
Waltersson, M.A.öm.; Askmalm, M.S.; Nordenskjöld, B.; Fornander, T.; Skoog, L.; Stål, O. 2009: Altered expression of cyclin e and the retinoblastoma protein influences the effect of adjuvant therapy in breast cancer International Journal of Oncology 34(2): 441-448
Driscoll, B.; Buckley, S.; Barsky, L.; Weinberg, K.; Anderson, K.D.; Warburton, D. 1999: Abrogation of cyclin D1 expression predisposes lung cancer cells to serum deprivation-induced apoptosis American Journal of Physiology 276(4): L679-L687
Vagliasindi, A.; Sivelli, R.; Gualtierotti, M.; Piccolo, D.; Bertagni, A.; Sianesi, M. 2003: Are small-size depressed-type colorectal neoplasias really the expression of a early stage of colorectal cancer. Apropos of a clinical case Tumori 89(4 Suppl): 155-158
Aaltomaa, S.; Kärjä, V.; Lipponen, P.; Isotalo, T.; Kankkunen, J.P.; Talja, M.; Mokka, R. 2006: Expression of Ki-67, cyclin D1 and apoptosis markers correlated with survival in prostate cancer patients treated by radical prostatectomy Anticancer Research 26(6c): 4873-4878
Kanczuga-Koda, L.; Koda, M.; Sulkowski, S.; Wincewicz, A.; Zalewski, B.; Sulkowska, M. 2010: Gradual loss of functional gap junction within progression of colorectal cancer -- a shift from membranous CX32 and CX43 expression to cytoplasmic pattern during colorectal carcinogenesis In Vivo 24(1): 101-107
Nikoleishvili, D.; Pertia, A.; Tsintsadze, O.; Gogokhia, N.; Chkhotua, A. 2007: Down-regulation of p27(Kip 1) cyclin-dependent kinase inhibitor in prostate cancer: distinct expression in various prostate cells associating with tumor stage and grades Georgian Medical News 143: 34-38
Kirlin, W.G.; Ogolla, F.; Andrews, A.F.; Trinidad, A.; Ferguson, R.J.; Yerokun, T.; Mpezo, M.; Hein, D.W. 1991: Acetylator genotype-dependent expression of arylamine N-acetyltransferase in human colon cytosol from non-cancer and colorectal cancer patients Cancer Research 51(2): 549-555
Valentini, A.M.; Pirrelli, M.; Armentano, R.; Caruso, M.L. 1996: The immunohistochemical expression of cathepsin D in colorectal cancer Anticancer Research 16(1): 77-80
Nihon-yanagi, Y.; Park, Y.; Ooshiro, M.; Terai, K.; Matsumoto, T.; Murano, T.; Okazumi, S. 2008: Expression of toll-like receptor 4 in colorectal cancer Gan to Kagaku Ryoho. Cancer and ChemoTherapy 35(12): 2247-2249