Immunology and progestins in pregnancy
Schindler, A.E.
Zentralblatt für Gynakologie 119(Suppl 2): 75-77
1997
ISSN/ISBN: 0044-4197 PMID: 9441545 Document Number: 471884
Indications for a relationship of corpus luteum/progesterone and rate of abortions are well known for some time. Measurement of progesterone and clinical observations could demonstrate, that low serum progesterone levels indicate even better than HCG-measurements an abnormal course of pregnancy. Early substitution seems to be the decisive therapeutic measurement. Progesterone leads in relation to the concentration at the feto-maternal interface to direct and indirect suppression of T-cell reactions. Progesterone acts synergistically with prostaglandin E2 immunosuppressive. The interleukin 2-induced cellular cytotoxity is suppressed. Progesterone induces a number of proteins such as PP 14, which inhibit the activity of T-cells and killer cells. The mitogenic lymphocyte reactivity is lowered. The results of immunological therapies up to now do not give proof of the effectiveness of immunological treatment modalities.