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A study on familial aggregation of hepatitis virus infection in Fujian province

Li, L.; Zhou, Y.; Wang, Z.

Zhonghua Yu Fang Yi Xue Za Zhi 31(6): 362-364

1997

ISSN/ISBN: 0253-9624
PMID: 9863073
Document Number: 471432
In nine disease surveillance points of Fujian Province, positive serum antibody against hepatitis A virus (anti-HAV), hepatitis B surface antigen (HBsAg), antibody against hepatitis Cvirus (anti-HCV) and antibody against hepatitis E virus (anti-HEV) in people of 1,237 families were determined and their distribution was analyzed to study familial aggregation of hepatitis virus infection by fitting to binomial distribution. Results showed that chi 2 of goodness-of-fit to binomial distribution was 49.89, 217.91 and 27.39 for anti-HAV, HBsAg and anti-HEV respectively, all with P < 0.001, indicating very obvious familial aggregation in HAV, HBV and HEV infection, with aggregation rates of 84.13%, 34.83% and 35.23% respectively. It suggests that familial aggregation is mainly caused by mother to infant transmission and horizontal transmission in families, and HEV infection can be transmitted through sex.

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