Adverse reactions and immune response to Heberbiovac-HB vaccine administered to infants simultaneously with DPT and VA-MENGOC-BC
Díaz González, M.; Rodríguez Lay, L.; López-Chávez, A.U.; Bravo González, J.R.; Pedroso Flaquet, P.
Revista Cubana de Medicina Tropical 49(3): 196-203
1997
ISSN/ISBN: 0375-0760 PMID: 9685987 Document Number: 471375
The Cuban recombinant yeast-derived hepatitis B vaccine (Heberbiovac-HB) was administered to 2 groups of infants aged 3 months. A dosage of 10 micrograms was used through a scheme of 0, 1 and 6 and 0, 1, 2 and 12, coinciding with the DPT and anti-meningococcal vaccines, according to the immunization schedule. Reactogenicity and immunogenicity were studied in both groups. The reactions observed were mild and similar to other studies, where fever , erythema and induration were the most common signs. These 2 groups had high percentages of children with titres of antibodies anti HBs above 100 UI/L-1. It is demonstrated the acceptable reactogenicity of the vaccine and the non-immunological interference of other vaccines.