Evaluation of phenazone oxidation and sulfadimidine acetylation in patients with hematologic neoplasms
Wiela-Hojeńska, A.; Milejski, P.; Orzechowska-Juzwenko, K.; Usnarska-Zubkiewicz, L.; Urbaniak-Kujda, D.; Kotlarek-Haus, S.
Przeglad Lekarski 54(3): 163-166
1997
ISSN/ISBN: 0033-2240 PMID: 9297191 Document Number: 470434
The aim of our study was to estimate of phenazone oxidation and sulfadimidine acetylation in patients with Hodgkins disease, non Hodgkins lymphoma and acute leukemia. We observed increase in liver microsomal enzyme activity and predominance of the rapid acetylator phenotype in these pathological states. It should be taken into account when dosing drugs which are metabolized as markers of the liver metabolic efficiency like phenazone and sulphadimidine. One can also expect these patients to have a genetic predisposition to the development of cancer disease.