HIV-protein-mediated alterations in T cell interactions with the extracellular matrix proteins and endothelium
Mrowiec, T.; Melchar, C.; Górski, A.
Archivum Immunologiae et Therapiae Experimentalis 45(2-3): 255-259
1997
ISSN/ISBN: 0004-069X PMID: 9597096 Document Number: 469807
Recent data point to the immunoregulatory role of extracellular matrix (ECM) proteins in the process of T cell activation. We studied the effects of HIV proteins on those interactions as well as on endothelial adhesion molecule expression. Gp 120 and gp 41 inhibited CD3-triggered T cell co-stimulation by the ECM proteins, while Nef was stimulatory. T cell adhesion to the ECM proteins was affected in a similar fashion. Furthermore, tat induced E-selectin (but not VCAM-1 and ICAM-1) endothelial expression. Those findings may be relevant for the understanding of immunopathology of AIDS.