Arthritis caused by use of rifabutine++ in Mycobacterium avium infection
Van Denderen, J.C.; Mensen, E.A.; Vints, A.M.
Nederlands Tijdschrift Voor Geneeskunde 141(42): 2028-2030
1997
ISSN/ISBN: 0028-2162 PMID: 9550756 Document Number: 469682
A 60-year-old HIV-seronegative man with a Mycobacterium avium pulmonary infection was treated with rifabutin, ethambutol and clarithromycin. He developed a serious arthritis which disappeared after interruption of the medication and recurred after resumption. The arthritis was attributed to the use of rifabutin. This adverse effect is more frequent with higher doses and in combination with the use of macrolide antibiotics.