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Mitochondrial nature of cardiomyopathies in children (analysis of skeletal muscle biopsies)

Sukhorukov, V.S.; Klembovskiĭ, A.I.; Nevstrueva, V.V.; Leont'eva, I.V.; Belozerov, I.M.; Sebeleva, A.I.

Arkhiv Patologii 59(5): 12-18

1997

ISSN/ISBN: 0004-1955
PMID: 9446528
Document Number: 469487
Morphological characteristics of the skeletal muscle biopsies from 10 children with idiopathic dilatational and hypertrophic cardiomyopathies are described. Methods of light and electron microscopy, histochemistry (mitochondrial enzymes, glycogen, lipids, calcium), morphometry and statistics were used. The presence of specific and nonspecific signs of systemic mitochondrial insufficiency, the character of histochemical distribution of the energetic substrates and the calcium suggest that this insufficiency is the basis of cardiomyopathies pathogenesis.

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