Cognitive effects of vigabatrin: a review
Monaco, F.
Neurology 47(1 Suppl 1): S6-S11
1996
ISSN/ISBN: 0028-3878 PMID: 8677033 Document Number: 469321
Studies were reviewed in which patients who received vigabatrin underwent cognitive testing. The overall results were categorized into five areas of cognitive function: reception, attention, intellectual function, memory, and psychomotor function. Overall, the studies showed either no detrimental effects or, in some cases, slightly improved function. It is speculated that a relationship exists between GABA and the results of these studies because vigabatrin enhances the GABAergic mechanism in the CNS.