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von Willebrand factor in diabetic retinopathy

Abayomi, E.A.; Miller, E.; Paton, R.C.

Central African Journal of Medicine 42(7): 205-206

1996

ISSN/ISBN: 0008-9176
PMID: 8936786
Document Number: 468847
Objective: To elucidate the qualitative nature of elevated levels of von Willebrand factor (vWF) in diabetic microangiopathy. Design: A randomized controlled Setting: Oxford Health Authority, Oxfordshire, United Kingdom. Subjects: Insulin dependent diabetic patients with established retinopathy, and an age, sex matched control group. Main Outcome Measures: Diabetic retinopathy, a modified enzyme-linked immunosorbent assay (ELISA), used to distinguish between endothelial and plasma type vWF. Results: vWF is higher in patients with diabetic retinopathy mean (217u/dl) compared with normal subjects mean (87u/dl). vWF in both patient and control are of the plasma type. Conclusion: vWF in diabetic retinopathy is raised and of the plasma type, suggesting it is not to acute vascular endothelial injury.

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