Antistreptococcal immunity in rheumatism and urban ecological risk factors
Amanzholova, S.A.
Terapevticheskii Arkhiv 68(5): 45-47
1996
ISSN/ISBN: 0040-3660 PMID: 9082598 Document Number: 466490
143 rheumatic patients and 40 healthy subjects exposed to different air pollution have been studied. In three representative groups the following parameters were studied: immunocompetent cell function (by leukocyte migration inhibition with streptococcal antigen), humoral response (by antibodies to streptococcus A polysaccharide shown at immunodiffusion), titres of antistreptolysin 0 (ASL0) and antistreptohyaluronidase (ASH). High hypersensitivity of delayed type was registered in patients from clean zones. In those breathing with polluted air there were elevated levels of antibodies to A-polysaccharide. ASL0 and ASH, their high titer in summer evidencing toxic influence of photo-oxidants. Based on the data obtained it is possible to predict the risk of greater rheumatism activity in zone with greater air pollution.