Genetics of manic depressive disorder
Oruc, L.; Cerić, I.; Furac, I.
Medicinski Arhiv 50(1-2): 45-47
1996
ISSN/ISBN: 0025-8083 PMID: 9333681 Document Number: 466258
Genetic transmission in manic depressive disorder (MDD) has been explored in linkage and association studies. The X-linked transmission hypothesis has been tested by using several markers on chromosome X. The hypothesis of autosomal transmission has been tested by association studies with the 0 blood group located on chromosome 9, as well as linkage studies on chromosome 6 and chromosome 11. Although linkage studies support the hypothesis of a major locus, several factors are limiting the results which are discussed in the present review.