Fc gamma RII-mediated regulation of human B cells
Gergely, J.; Sármay, G.
Scandinavian Journal of Immunology 44(1): 1-10
1996
ISSN/ISBN: 0300-9475 PMID: 8693285 Document Number: 466220
Recent studies have provided considerable insight into the mechanism of BCR-mediated B-cell activation, but the inhibitory signals transferred by Fc gamma Rs leading to down-regulation of BCR-activated B lymphocytes are not clarified yet. In the present paper the authors give an overview on new findings regarding BCR structure and signal transduction mechanisms induced by the B-cell antigen receptor complex and outline, partly based on their own observations, the possible mechanisms resulting in Fc gamma R-mediated inhibition of B cells.
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