Clinical pharmacology of 2-chlorodeoxyadenosine (Cladribine)
Góra-Tybor, J.; Robak, T.
Przeglad Lekarski 53(8): 614-618
1996
ISSN/ISBN: 0033-2240 PMID: 8999463 Document Number: 466141
2-chlorodeoxyadenosine (2-CdA) is a simple nucleoside derived from deoxyadenosine by substituting chloride for hydrogen in 2' position of the purine ring, which renders it resistant to degradation by adenosine deaminase. Many studies have revealed high efficiency of 2-CdA in the treatment of lymphoid malignancies. Hairy cell leukemia is notably responsive to 2-CdA, with 85% of patients entering complete remissions after treatment of this drug.