The role of the polymorphonuclear neutrophil in the failure of multiple organs and systems
Fontes, B.; Sergio Poggetti, R.
Revista do Hospital das Clinicas 51(1): 21-25
1996
ISSN/ISBN: 0041-8781 PMID: 8762651 Document Number: 465202
The role of the polymorphonuclear neutrophil (PMN) on MOF is analyzed either as PMN activation for superoxide and enzyme release, or as PMN function depression after trauma and surgery. The authors stress: 1) the signal transduction pathway from the PMN membrane receptors to the effector response; 2) the PMN-NADPH system structure and function; 3) the functional states of the PMN (quiescente, primed, activated, non-responsive) in terms of the NADPH system activation; 4) the mechanism of tissue injuiry by the PMN. Clinical investigations on the PMN activation state, and therapeutical goals based on recent clinical investigations are also discussed.