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Apoptosis related gene, Pim-1

Ariga, H.; Iguchi-Ariga, S.M.

Nihon Rinsho. Japanese Journal of Clinical Medicine 54(7): 1903-1906

1996

ISSN/ISBN: 0047-1852
PMID: 8741685
Document Number: 465057
Pim-1, a protooncogene product, induced tumor in the combination with MYC. So far, two reports were published concerning Pim-1 function to apoptosis. One was that Pim-1 inhibit apoptosis in Pim-1 introduced transgenic mouse with a background of lpr/lpr, in which Fas was abrogated. However, the other that Pim-1 induced apoptosis in a transient expression system was also reported. In this communication, we survey the possible functions of Pim-1 in terms of the factor related to apoptosis and carcinogenesis.

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