Characterization of the MCC gene product
Matsumine, A.
Nihon Rinsho. Japanese Journal of Clinical Medicine 54(4): 981-985
1996
ISSN/ISBN: 0047-1852 PMID: 8920660 Document Number: 464916
MCC is a gene located within human chromosome band 5q21 that shows somatically acquired mutations in colorectal cancer. Here we report the identification, tissue specific distribution, subcellular localization, and growth regulating activity of MCC protein. Immunohistochemical analysis of MCC protein in various tissues of mouse revealed heavy cytoplasmic staining of brain neuronal cells and intestinal epithelial cells. Ectopic expression of the MCC gene by microinjection in normal NIH3T3 cell lines leads to inhibition of DNA synthesis. These studies provide some initial clues to the function of the MCC protein and demonstrate that it negatively controls the cell cycle progression.