Postoperative urinary ulinastatin secretion and renal function in hepatectomized patients with and without liver cirrhosis
Ueki, M.; Yokono, S.; Nogaya, J.; Taie, S.; Komatsu, H.; Ogli, K.
Masui. Japanese Journal of Anesthesiology 45(2): 178-182
1996
ISSN/ISBN: 0021-4892 PMID: 8865705 Document Number: 464408
We compared ulinastatin secretion into urine with renal function during postoperative period in three groups, hepatectomized group with liver cirrhosis (LC (+), n = 7), hepatectomized group without liver cirrhosis (LC(-), n=4) and subtotal gastrectomized group with normal liver function (GR, n=7). In LC(+) group, N-acetyl-BETA-D-glucosaminidase (NAG) increased above normal upper limit throughout the postoperative period. Ulinastatin (UTI) also increased but the increase was not remarkable. In LC(-) group, NAG increased but not significantly compared with the preoperative value. UTI increased from 5.8 +- 3.0 IU cntdot mg times Cr-1 to 30.8 +- 16.6 IU cntdot mg times Cr-1 and 39.9 +- 9.0 IU cntdot mg times Cr-1 on the 1st and 3rd postoperative day respectively. In GR group, there was no change in NAG value. UTI on the 3rd postoperative day increased significantly (from 10.0 +- 7.7 to 75.4 +- 39.0 IU cntdot mg times Cr-1). A small urinary secretion of UTI and increased NAG during postoperative period in LC (+) group suggest that UTI might play an important role in postoperative renal dysfunction in patients with liver cirrhosis.