The age-dependent incidence of Down's syndrome and the free-radical theory
Arbuzova, S.B.
Tsitologiia i Genetika 30(5): 27-35
1996
ISSN/ISBN: 0564-3783 PMID: 9026987 Document Number: 463943
Age-dependent distribution of Down syndrome frequency in the light of free-radical theory of aging was carried out in this work. The frequency of Down syndrome had been analysed during the period of 1990-1995. The investigation of radical process intensity was performed in the group of women of child-bearing age by the chemoluminescence method. It has been demonstrated that the age of a woman is one of the main reasons both of Down syndrome frequency increase and free radical accumulation. The obtained analogy between age-dependent distribution of Down syndrome frequency and age-dependent accumulation of free radicals is one more argument for the role of free radicals in the pathogenesis of Down syndrome.