Simultaneous screening of HPV-6b and 16 in pharyngolaryngeal cancer
Alvarez Alvarez, I.; Sánchez Lazo, P.; Ramos González, S.; Rodrigo Tapia, J.P.; Llorente Pendas, J.L.; Suárez Nieto, C.
Acta Otorrinolaringologica Espanola 47(2): 93-96
1996
ISSN/ISBN: 0001-6519 PMID: 8695213 Document Number: 463433
It has been suggested that some human papilloma viruses (HPV) may play a causal role in cancer of the pharynx, larynx, and oral cavity, together with factors such as smoking, alcohol, toxins, and heredity. Using the polymerase chain reaction (PCR), we detected the two most common genotypes in pharyngolaryngeal cancer, HPV-6b and 16, in 15 patients from a series of 57 cases. One patient had both genotypes. The fact that this was the only positive case in which no other risk factors were present, particularly alcohol and smoking, suggests that the synergetic oncogenic action of both viruses could have played an important role in carcinogenesis.