Gastric adenocarcinoma in hamartomatous polyp in Peutz-Jeghers syndrome
Bujanda, L.; Beguiristain, A.; Villar, J.M.; Cosme, A.; Castiella, A.; Arriola, J.A.; Arenas, J.I.
Gastroenterologia y Hepatologia 19(9): 452-455
1996
ISSN/ISBN: 0210-5705 PMID: 8998668 Document Number: 463098
The Peutz-Jeghers syndrome is characterized by gastrointestinal polyposis and mucocutaneous melanin pigmentation. Between the complications are the appearance of gastrointestinal neoplasms. There is an increasing evidence suggesting the hamartoma-adenoma-carcinoma sequence in Peutz-Jeghers syndrome. We present a 32-years-old man with Peutz-Jeghers syndrome who developed an adenocarcinoma arising in a gastric hamartomatous polyp. We discuss the risk to develop gastrointestinal neoplasms and the necessity for periodic surveillance.