Small-cell lung cancer and subacute sensory neuropathy in a patient positive for the anti-Hu antigen
Okishio, K.; Kudoh, S.; Katsumoto, E.; Ohtsuka, T.; Shoji, S.; Fujii, T.; Kanazawa, H.; Hirata, K.; Kurihara, N.; Yoshikawa, J.
Nihon Kyobu Shikkan Gakkai Zasshi 34(7): 816-821
1996
ISSN/ISBN: 0301-1542 PMID: 8810765 Document Number: 463026
We encountered a case of small-cell lung cancer in a patient with subacute sensory neuropathy that began 5 months before the cancer was diagnosed. A 60-year-old man complained of abnormalities in the functioning of his peripheral sensory systems (senses of pain, touch, position, and vibration). A chest X-ray film obtained on admission showed an anterior mediastinal tumor. The anti-Hu antibody was found in his serum. The diagnosis was small-cell lung cancer. Combination chemotherapy (cisplatin and irinotecan, CPT-11) was begun and the response was a complete remission. The symptoms of neuropathy continued. The anti-Hu antibody was useful in the diagnosis in the case of small-cell lung cancer combined with subacute sensory neuropathy.