The main peritoneal source of precursors of the murine intestinal IgA plasma cell
Kim, S.H.; Kim, T.H.; Han, D.U.
Anticancer Research 16(5a): 2821-2824
1996
ISSN/ISBN: 0250-7005 PMID: 8917391 Document Number: 462554
Previous reconstitution studies in irradiated mice distinguished B-1 from other B cells. The observation that approximately half of the B cells in the murine intestinal lamina propria are derived from peritoneal B-1 cell precursors raises the question of the derivation of their subsets (B-1a or B-1b). We examined the origin of IgA plasma cells in mice by reconstituting lethally irradiated mice with syngeneic adult bone marrow cells or fetal liver cells from syngeneic donors. We compared the level of copro IgA, the number of peritoneal B cell subsets, and differences in the IgA-positive plasma cell population in the lamina propria of the gut. The peritoneal B-1a cells were predominantly found in the fetal liver-transplanted mice rather than bone marrow-transplanted mice, but tile level of copro IgA and the population of IgA plasma cells were not significantly different between two experimental groups. Tile results suggest that the main source of peritoneally derived B cells in the lamina propria of the gut may be B-1b cells.