Hemophilia B in a mixed breed male dog: treatment of a hemorrhagic crisis with fresh frozen plasma
Mischke, R.; Haenies, R.; Deniz, A.; Hart, S.
Deutsche Tierärztliche Wochenschrift 103(1): 3-6
1996
ISSN/ISBN: 0341-6593 PMID: 8647012 Document Number: 462217
A 6 months old male crossbred dog became conspicuous because of a considerable haematoma in the region of the left thigh without recognizable exterior trauma. The results of the screening tests of the haemostatic system (distinctly prolonged activated partial thromboplastin time (aPTT), normal thromboplastin time and platelet count as well as a shortening of thrombin time) yielded a tentative diagnosis of haemophilia. Haemophilia B could be diagnosed on the basis of a distinctly and isolated reduced factor IX activity (8%, reference range: 70-140%). Two infusions with 20 ml/kg BW fresh frozen plasma each caused a clear clinical recovery of the patient. In addition, the efficacy of plasma infusion was documented in vitro by a temporary increase of factor IX activity as well as repeated measurements with the resonance thrombograph and of the aPTT.