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T cell receptor V beta repertoire in Crohn's disease

Matsumoto, T.; Kobayashi, K.

Nihon Rinsho. Japanese Journal of Clinical Medicine 54(4): 1182-1187

1996

ISSN/ISBN: 0047-1852
PMID: 8920694
Document Number: 461904
Although the pathogenesis of Crohn's disease remains yet clarified, impaired immunologic stimuli in intestinal mucosa may play an important role in the disease. T cell receptor repertoire, which recognizes antigens in conjunction with class II MHC molecules, reflects characteristics of antigenic stimuli related to the disease. In lamina propria lymphocytes in patients with Crohn's disease, skewing in T cell receptor V beta repertoire was confirmed in T cell clones generated from early aphtous lesion. Most of them showed oligoclonal expansion in some subsets of V beta. These results suggest that lamina propria lymphocytes were selectively stimulated by the local antigens closely related to the pathogenesis of the disease.

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