Immunomodulation after parenteral glutamine administration in colorectal surgery
Morlion, B.J.; Siedhoff, H.P.; Joosten, U.; Köller, M.; König, W.; Fürst, P.; Puchstein, C.
Langenbecks Archiv für Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft für Chirurgie. Kongress 113: 342-344
1996
ISSN/ISBN: 0942-2854 PMID: 9101871 Document Number: 461782
The influence of parenteral L-alanyl-L-glutamine dipeptide on the cysteinyl-leukotriene (cys-LT) synthesizing capacity from neutrophils was studied in patients undergoing colonic surgery. The decrease in cys-LT, observed postoperatively, could be normalized with parenteral glutamine, while the cys-LT decrease persisted in controls. We conclude that the provision of glutamine in the postoperative state improves normalization of neutrophil functions (e.g., generation of cys-LT), which is an essential prerequisite for host defences.