Expression of transforming growth factor alpha and p53 in non-small cell lung cancer by immunohistochemical study
Wang, H.; Chen, L.; Lin, L.
Zhonghua Zhong Liu Za Zhi 18(2): 84-87
1996
ISSN/ISBN: 0253-3766 PMID: 9206035 Document Number: 459924
Primary non-small cell lung cancer samples were examined for the expression of p53, transforming growth factor alpha (TGF-alpha) and its receptor EGF-R by immunohistochemistry. Accumulation of p53 protein was found in 15 out of 24 carcinomas. Meanwhile, the results of TGF-alpha and p53 expression in 21 carcinomas showed that p53 protein was not detected in 2 out of 2 TGF-alpha negative and 4 out of 5 TGF-alpha low expression cases. However, there was no relationship found between EGF-R and p53 expression in these cases. The results suggest that p53 may have some effects on TGF-alpha expression.