The successful use of hyperstimulated washed therapeutic donor insemination after standard therapeutic donor insemination has failed
Dow, M.P.; Jones, J.M.; Dumesic, D.A.; Lu, Y.; Shapiro, S.S.
International Journal of Fertility and Menopausal Studies 41(6): 516-521
1996
ISSN/ISBN: 1069-3130 PMID: 9010745 Document Number: 459684
To investigate whether an aggressive therapeutic donor insemination regimen (stimulated folliculogenesis and ovulation plus intrauterine insemination) can produce a better fecundability rate than a more traditional insemination regimen (non-stimulated folliculogenesis plus LH-timed intracervical insemination) in women who have failed to become pregnant during an initial series of six traditional insemination cycles. A retrospective comparison of fecundability rates was undertaken between women undergoing the traditional insemination protocol and those who voluntarily switched to ovarian hyperstimulation coupled with intrauterine insemination. Eight-two women who failed to become pregnant during an initial series of six intracervical insemination cycles. Fecundability was 5.6% in cycles of continued urinary LH-timed intracervical insemination and 19.4% when the more aggressive regimen was applied. The difference in fecundability between protocols was significant (P < .005). After an initial series of donor inseminations has failed, a more aggressive insemination regimen involving ovarian hyperstimulation followed by washed intrauterine insemination provides a higher fecundability rate than continued intracervical insemination.