Assessment of chlorpromazine as radiation sensitizer and protector
Huilgol, N.G.; Chatterjee, N.; Singh, B.B.
Indian Journal of Cancer 33(4): 195-200
1996
ISSN/ISBN: 0019-509X PMID: 9255000 Document Number: 459589
In vitro studies of chlorpromazine (CPZ) a popular anti-psychotic drug has shown radiation sensitizing effects at higher cellular concentration and protective effect at a lower concentration. The present study was designed to evaluate both sensitizing and protective effects in the treatment of advanced cancer of the cervix treated with hypofractionated external radiation and intratumoural injection of chlorpromazine. Twenty patients were treated with intratumoural CPZ and radiation, while, 23 patients received radiation alone. A 52.94% complete response was noted in CPZ arm while 39.1% complete response in the control. A trend towards improved response is seen in CPZ group. Similarly patients who received CPZ showed significantly low proctitis rates.