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Negative cooperativity of 6-phosphogluconate dehydrogenase in rat liver

Voĭnova, N.E.; Chesnokova, L.S.; Lyzlova, S.N.

Biokhimiia 61(3): 451-454

1996

ISSN/ISBN: 0320-9725
PMID: 8724602
Document Number: 459281
The effect of various NADPH concentrations on the activity of rat liver 6-phosphogluconate dehydrogenase (EC 1.1.1.44) has been studied. The influence of NADPH concentrations on the enzyme cooperativity was observed. NADPH used at concentration up to 200 microM appeared to be a competitive inhibitor with respect to NADP+ without any cooperative effect towards the coenzyme (NADP+) binding. At high concentrations of NADPH (above 300 microM) the negative cooperativity displayed by the enzyme was confirmed by a significant decrease of the Hill coefficient for NADP(+)-from 1.1 +/- 0.2 down to 0.6 +/- 0.1 (p < 0.05).

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