Correlation of MMTV antibody expression and risk factors of human breast cancer
Riabykh, T.P.; Malivanova, T.F.; Litvinov, S.V.; Gel'fand, E.V.; Kriukova, I.N.
Voprosy Onkologii 42(2): 40-45
1996
ISSN/ISBN: 0507-3758 PMID: 8815632 Document Number: 458608
Incidence of sera with antibodies to MMTV-related proteins has been studied in a cohort at high risk for breast cancer including healthy females and those with benign breast disease. The results were evaluated versus certain risk factors of breast cancer. No significant difference in the incidence was established between cases of diffuse fibrocystic mastopathy and healthy subjects. Nor was there any relationship between positive serum incidence and age, number of abortions, age at first childbirth or postmenopause. However, this parameter appeared to be in direct correlation with the number of childbirths (beginning from 3). This index was significantly higher in women (aged 40 and more) with early menarche than in those with medium and late menarche (8 and 0%, respectively).