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Effect of captopril on intracellular pH in vascular smooth muscle cells

Qi, J.H.; Zhang, L.; Wang, J.; Gu, P.K.; Jin, Z.J.; Huang, M.Z.; Wang, X.M.

Zhongguo Yao Li Xue Bao 17(5): 448-450

1996

ISSN/ISBN: 0253-9756
PMID: 9863172
Document Number: 457337
AIM: To observe the effect of captopril (Cap) on intracellular pH (pH-i) in aortic smooth muscle cells (ASMC). METHODS: Cultured ASMC derived from rat and rabbit aortae were loaded with the fluorescent dye BCECF and pH-i was determined using digital image processing method. RESULTS: The pH-i of untreated SHR and WKY rats were 7. 37 +- 0.29 and 7.19 +- 0.31, respectively. Oral Cap decreased pH-i (7.11 +- 0.26, P lt 0.05) and exaggerated pH-i response to angiotensin II (Ang-II, 0.1 mu-mol cntdot L-1) in ASMC of SHR rats vs WKY rats 0.14 +- 0.05 vs 0.21 +- 0.05 pH units, P lt 0.01). Cap in vitro had no effect on Ang-II induced intracellular alkalinization in ASMC of rabbits. CONCLUSION: Oral Cap inhibits Na+ - H+ exchange activity in ASMC of SHR rats.

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