Cerebral blood volume, cerebral hemoglobin and cytochrome AA3 during hypotension induced by prostaglandin E1 or epidural anesthesia under general anesthesia
Shinohara, M.; Ogata, H.; Kitajima, T.
Masui. Japanese Journal of Anesthesiology 45(8): 961-966
1996
ISSN/ISBN: 0021-4892 PMID: 8818092 Document Number: 456510
The effect of hypotension induced by PGE-1 or epidural anesthesia under general anesthesia on cerebral blood volume (CBV), cerebral tissue hemoglobin, cytochrome AA-3 was studied using a near infrared spectrophotometry in 20 patients undergoing abdominal operation. In PGE-1 group (n = 10), CBV, cerebral oxyhemoglobin (HbO-2) and deoxyhemoglobin (Hb) were unchanged during hypotension. However, cerebral HbO-2 decreased and Hb increased slightly in a case of severe hypotension more than 40 percent of control, but CBV did not show any significant change. On the other hand, in epidural anesthesia group, HbO-2 decreased significantly along with MAP reduction (r=0.84) and Hb increased slightly. Cytochrome AA, did not show any significant changes in both groups. From these results, we concluded that PGE-1 drip infusion was better than epidural anesthesia to sustain the cerebral blood volume during hypotension.