The limitation of glucose catabolism as a factor in protection during hypoxia
Burbello, A.T.; Vishvtseva, V.V.; Denisenko, P.P.; Safonova, A.F.; Dobrokhotova, E.G.
Eksperimental'naia i Klinicheskaia Farmakologiia 58(1): 49-52
1995
ISSN/ISBN: 0869-2092 PMID: 7787699 Document Number: 454671
Violuric acid was first shown to have antihypoxic and antioxidative properties, to exert protective action in sodium nitrite-induced hemic hypoxia. Hepatic glucose and glucogen levels increased, the activity of glucose-6- phosphodihydrogenase enhanced, while that of lactate dehydrogenase and alkaline phosphatase decreased, the content of cAMP restored, whereas cGMP and 2,3-diphosphoglycerate levels decreased to a greater extent. The action of violuric acid was especially evident at the ultrastructural level-the ultrastructure of brush receptor elements in anoxia in the presence of violuric acid's action retained all the features characteristic for intact animals, which was accompanied by a significant accumulation of glycogen in the neuroplasm.