Clinical effects and immunological analysis of intraabdominal and intrapleural injection of lentinan for malignant ascites and pleural effusion of gastric carcinoma
Hazama, S.; Oka, M.; Yoshino, S.; Iizuka, N.; Wadamori, K.; Yamamoto, K.; Hirazawa, K.; Wang, F.; Ogura, Y.; Masaki, Y.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 22(11): 1595-1597
1995
ISSN/ISBN: 0385-0684 PMID: 7574768 Document Number: 454577
Twenty-one patients with malignant peritoneal or pleural effusions of gastric carcinomas were treated with intracavitary injection of lentinan (LNT). LNT was injected at a dosage of 4 mg/week for 4 weeks. In total, fifteen (71%) of twenty-one patients demonstrated clinical responses. Toxicity caused a high fever in only one case. LAK and ATK activities induced from peritoneal exudate cells (PEC) after culture with autologous tumor and interleukin-2 were examined before and after LNT injection. ATK activity was augmented, but LAK activity was reduced after LNT injection. These results indicate that intracavitary injection of LNT is a useful treatment for malignant effusions, and that LNT augments the induction of cytotoxic T-lymphocytes.