Therapy of arrhythmia induced by myocardial ischemia. Association of L-carnitine, propafenone and mexiletine
Mondillo, S.; Faglia, S.; D'Aprile, N.; Mangiacotti, L.; Campolo, M.A.; Agricola, E.; Palazzuoli, V.
La Clinica Terapeutica 146(12): 769-774
1995
ISSN/ISBN: 0009-9074 PMID: 8681496 Document Number: 454032
To assess the anti-arrythmic effect of L-carnitina, propafenone and mexiletine, we tested the drugs in 50 patients with effort angina and ventricular ectopic beats (VEB). The patients were randomized in 5 groups: Group A: was treated with oral L-carnitine at the dose of 2 g x 3 for two weeks. Group B: oral propafenone at the dose of 300 mg x 3 for two weeks. Group C: as group B+L-carnitine+g x 3 at the second weeks. Group D: oral mexiletine at the dose of 200 mg x 3 for two weeks. Group E: as group D+L-carnitine 2 gr x 3 at the second week. After 7 and 14 days of treatment, in all patients an Holter examination was performed. Our results show that L-carnitine exerts a significant reduction of the VEB and its administration potentiates the anti-arrythmic effect of propafenone and mexiletine.