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The role of protein kinase C and muscarinic cholinoreceptors in vasopressin-stimulated water transport

Bagrov, I.Iu.; Dmitrieva, N.I.; Manusova, N.B.

Eksperimental'naia i Klinicheskaia Farmakologiia 58(4): 33-35

1995

ISSN/ISBN: 0869-2092
PMID: 7580750
Document Number: 453875
The role of proteinkinase C (PKC) in the control of vasopressin-stimulated water transport in the frog urinary bladder and its modulation by M2-agonist oxotremorine has been studied. Using the PKC inhibitor, staurosporine we showed that PKC in the region pf the basal membrane suppressed vasopressin-stimulated water transport, whereas PKC in the apical region potentiated this transport. It was also found that from the two types of oxotremorine action on stimulated water transport determined by its concentration only inhibition is mediated through PKC.

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