Assessment of anxiolytics (1) --Geller-type conflict tests
Kuribara, H.
Nihon Shinkei Seishin Yakurigaku Zasshi 15(2): 115-123
1995
ISSN/ISBN: 1340-2544 PMID: 7796316 Document Number: 453090
The Geller-type conflict test and its modified tests, which are based on operant conditioning, have been applied for preclinical evaluation of the anxiolytic effect of drugs in parallel with the clinical use of benzodiazepines. Here, the author describes the experimental procedures of the Geller-type conflict test, including its modified tests, using mice and rats in detail. The effects of drugs, particularly benzodiazepines and 5-HT-1A receptor agonists, on the established conflict behaviors in rats and mice are also presented.