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Autoantibodies in Parry-Romberg syndrome: a serologic study of 14 patients

Garcia-de la Torre, I.; Castello-Sendra, J.; Esgleyes-Ribot, T.; Martinez-Bonilla, G.; Guerrerosantos, J.; Fritzler, M.J.

Journal of Rheumatology 22(1): 73-77

1995

ISSN/ISBN: 0315-162X
PMID: 7699686
Document Number: 452039
Objective: To determine autoantibody profiles of patients with Parry-Romberg syndrome (PRS). Methods: Antinuclear antibodies (ANA) in 14 patients with PRS were studied by indirect immunofluorescence (IIF), immunodiffusion and immunoblotting. Antinative DNA antibodies and rheumatoid factor (RF) were also analyzed. Results: ANA were positive in 8 patients (57%). The patterns of staining included nucleolar, nuclear speckled and homogeneous. Anticentromere antibodies were observed in 2 and antihistone antibodies in 3 sera. Rheumatoid factor was found in 5 (36%) sera. Antinative DNA or antibodies that precipitated rabbit thymus extract were not found in any patients. Conclusion: The serologic abnormalities observed in this study suggests that autoimmunity could play a pathogenic role in PRS.

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