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Structure and function of tumor suppressor genes

Akiyama, T.

Nihon Rinsho. Japanese Journal of Clinical Medicine 53(11): 2654-2659

1995

ISSN/ISBN: 0047-1852
PMID: 8538021
Document Number: 451854
Tumor suppressor genes encode molecules involved in cell adhesion, cytoplasmic signal transduction, transcriptional regulation and DNA repair. Recent studies have shown that p53 and WT1 regulate the cell cycle by altering the expression of genes involved in controlling the activity of cyclin/CDK complexes. By contrast, RB regulates the expression of genes that mediate cell cycle progression from the G1 to S phase and its activity is negatively regulated by cyclin/CDK. Recent progress in this field is summarized in the light of cell cycle control.

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