Insulin and prostaglandins as signals between tumor and the host immune system
Curi, R.; Homem-de-Bittencourt, P.I.; Costa-Rosa, L.F.; Fernandes, L.C.; el-Razi, S.; Seelaender, M.C.; Carpinelli, A.R.
Brazilian Journal of Medical and Biological Research 28(7): 773-779
1995
ISSN/ISBN: 0100-879X PMID: 8580869 Document Number: 451088
The development of malignant tissue in vivo is partially favored by the immunosuppression that occurs in cancer patients. However, the signals between tumor and immune tissues remain to be identified. We present evidence that prostaglandins may act as one of these signals by a direct action on cells of the immune system, or by inhibition of insulin secretion which in turn suppresses immune function, or both.