Effects of preoperatively administered flurbiprofen axetil on the action of inhaled anesthesia and postoperative pain
Yamazaki, Y.; Sonoda, H.; Seki, S.
Masui. Japanese Journal of Anesthesiology 44(9): 1238-1241
1995
ISSN/ISBN: 0021-4892 PMID: 8523657 Document Number: 450868
Flurbiprofen axetil (FP) was evaluated in a randomized study relative to placebo in 26 patients undergoing endonasal ethmoidectomy. The FP group (n = 13) was administrated 1 mg cntdot kg-1 FP 15 minutes before operation during a half hour. Likewise, the control group (n=13) received intravenous NaCl 0.9%. Concentration and the quantity consumed of sevoflurane, perioperative body temperature, postoperative pain and on-demand diclofenac sodium consumption were measured. No significant differences were observed concerning concentration and the quantity consumed of sevoflurane. Body temperature of the FP group fell significantly before infusion. The FP group showed lower pain scores and required less diclofenac sodium than the control group (P lt 0.05). This study suggests that preoperative FP infusion relieves postoperative pain, but does not affect the action of the inhalation anesthetic.