Prognostic relevance of Ki-67 antigen and c-myc oncoprotein in malignant fibrous histocytoma
Brinck, U.; Stachura, J.; Kellner, S.; Schauer, A.
Anticancer Research 15(5b): 1915-1919
1995
ISSN/ISBN: 0250-7005 PMID: 8572578 Document Number: 450204
47 cases of malignant fibrous histiocytoma were stained immunohistochemically for the presence of Ki-67 antigen and c-myc oncoprotein. Percentage of Ki-67 and c-myc positive cells correlated with each other and with grade of tumour, mitotic index, cellularity and survival time of patients, but not with the extent of necrosis. Differences of mean values of Ki-67 index between grade I and grade III tumours as well as between grade II and grade III tumours were highly statistically significant. All 3 parameters connected with c-myc expression (index, intensity and score) differed significantly between grade I and grade II tumours but not between grade II and grade III MFH. The possible differential role of Ki-67 antigen and c-myc oncoprotein for improvement of grading is discussed.