Do oral contraceptives inhibit Trichomonas vaginalis?
Bramley, M.; Kinghorn, G.
Sexually Transmitted Diseases 6(4): 261-263
1979
ISSN/ISBN: 0148-5717 PMID: 316933 DOI: 10.1097/00007435-197910000-00009Document Number: 449418
OC (oral contraceptive) therapy has been implicated with vaginal yeast infections. This study compares OC users with and without various genital infections. 1143 women attending the Sheffield Special Treatment Clinic were grouped retrospectively as follows: 114 had trichomoniasis alone, 179 had yeast infections alone, 333 had gonorrhea, and 517 had no genital infections. OC usage was found to be significantly less among women with trichomoniasis alone (p 0.002) as compared with those who had yeast infection (p 0.001) alone and those who had no genital infection. There was a 95% rate of cure of trichomoniasis among all groups of women treated with a single oral dose of 2 g of metroniadazole. The findings suggest that OCs may inhibit trichomoniasis but enhance vaginal yeast infections.